The present invention covers substituted 3-Phenylquinazolin-4(3H)-one compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of various inflammatory and fibrotic diseases of the respiratory tract and of the lungs as well as lung cancer, as a sole agent or in combination with other active ingredients.本發明包括如本文所述和定義的取代的3-苯基喹唑啉-4-(3H)-酮化合物，製備所述化合物的方法，用於製備所述化合物的中間體化合物，包含所述化合物的藥物組合物和組合，以及所述化合物在製備用於治療或預防疾病的藥物組合物中的用途，特別是用於治療和/或預防呼吸道和肺部的各種炎性和纖維化疾病以及肺癌的用途，作為唯一的藥劑或與其他活性成分組合。
