DUFFEY, MATTHEW O.,杜飞 麦修O,杜飛 麥修O,ENGLAND, DYLAN,英格兰 迪伦,英格蘭 迪倫,FREEZE, SCOTT,芙兹 史考特,芙茲 史考特,HU, ZHIGEN,胡志根,胡志根,LANGSTON, STEVEN P.,兰斯敦 史帝芬P,蘭斯敦 史帝芬P,MCINTYRE, CHARLES,麦欣泰尔 查理斯,麥欣泰爾 查理斯,MIZUTANI, HIROTAK
申请号：
TW104121240
公开号：
TW201613903A
申请日:
2015.06.30
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
Disclosed are chemical entities which are compounds of formula (I): or pharmaceutically acceptable salts thereof wherein Y, Ra, Ra, Rb, Rc, X1, X2, X3, Rd, Z1, and Z2 have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry. Chemical entities according to the disclosure can be useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders.本發明揭示如下化學實體,其為式(I)化合物:或其醫藥學上可接受之鹽;其中Y、Ra、Ra、Rb、Rc、X1、X2、X3、Rd、Z1及Z2具有本文中所述之值,且在加星號之位置描繪之立體化學組態指示絕對立體化學。根據本發明之化學實體可用作Sumo活化酵素(SAE)抑制劑。進一步提供包含本發明化合物的醫藥組合物,及使用該等組合物治療增生性、發炎性、心血管及神經退化性疾病或病症之方法。
