BAXALTA INCORPORATED;BAXALTA GMBH;BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE SA
发明人:
申请号：
IL22392912
公开号：
IL223929A
申请日:
2012.12.27
申请国别(地区):
IL
年份:
2017
代理人:
摘要：
Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a high specific activity and ADAMTS 13 with a high specific activity. The cell culture conditions of the present invention can include, for example, a cell culture medium with an increased copper concentration and/or cell culture supernatant with a low ammonium (NH 4 + ) concentration. The present invention also provides methods for cultivating cells in the cell culture conditions to express high molecular weight vWF and rA13 having high specific activities.
