An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein:(i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide(ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure and(ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions.Use of the peptides and titanium devices comprising same are also disclosed.
