BHAGYA L. CHANDRASHEKAR,HARISH RAVIVARAPU,JOHN S. GARRETT,RICHARD L. DUNN
申请号：
BR0114069
公开号：
BRPI0114069B1
申请日:
2001.09.21
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
"Leuprolide polymeric release formulations with improved efficacy". The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. the flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in the aqueous vehicle or body fluid. the flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in the aqueous vehicle or body fluid. The flowable composition also includes leuprolide acetate. The present invention is also directed to a method for forming the flowable composition. The present invention is also directed to a biodegradable implant formed in situ in a patient. The biodegradable implant is formed by injecting a flowable composition into the patient's body and allowing the biocompatible polar aprotic solvent to dissipate to produce a solid biodegradable implant. The present invention is also directed to a method of forming a biodegradable implant in situ in a living patient. The method includes injecting a flowable composition into a patient's body and allowing the biocompatible polar aprotic solvent to dissipate to produce a solid biodegradable implant. The present invention is also directed to a method of treating cancer in a patient. The method includes administering to the patient in need of such treatment an effective amount of a flowable composition of the present invention. The present invention is also directed to a method for reducing lhrh levels in a patient. The method includes administering to the patient in need of such a 1hrh reduction an effective amount of a flowable composition of the present invention. The present invention is also directed to a kit. The kit includes a first container and a second container. The first container includes a composition comprising a biocompatible polar aprotic solvent and a biodegradable thermoplastic polyester. The second co
