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Stabilization of liquid solutions of recombinant protein for frozen storage
专利权人:
Nelly Tsvetkova
发明人:
Nelly Tsvetkova,Omkar Joshi,Paul Wu,Deqian Wang,Arnaud Desponds
申请号:
US13459806
公开号:
US08536125B2
申请日:
2012.04.30
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a carbohydrate to said solution in an amount sufficient that, upon freezing, the solution has a glass transition temperature of −56° C. or higher.
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中国工程科技知识中心
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