Stabilization of liquid solutions of recombinant protein for frozen storage

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专利权人:

Nelly Tsvetkova

发明人:

Nelly Tsvetkova,Omkar Joshi,Paul Wu,Deqian Wang,Arnaud Desponds

申请号：

US13459806

公开号：

US08536125B2

申请日:

2012.04.30

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a carbohydrate to said solution in an amount sufficient that, upon freezing, the solution has a glass transition temperature of −56° C. or higher.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/