SAPOUNTZIS, IOANNIS,STADTMUELLER, HEINZ,KUHN, DANIEL
申请号：
PE0020122011
公开号：
PE03702012A1
申请日:
2010.05.28
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a 2.4 - diaminopyrimidine Derivative of formula (1), where a is aryl or heteroaryl C6 C15 5 to 12 members b is aryl or heteroaryl C6 C10 5 to 10 members R1, R2, R4 and RX are h, RA, RB, among others R3 is nrcrc, N (ORC), RC, RC (o) n [c] 2, among others R5 is Halogen, CN, CO2, ORC, ent Other RE RA is c1-c6 alkyl, cycloalkyl, aryl - C10 C3, C6 C10, among others rb = or, ORC, ocf3,Among others, is H RC, RD, re, RD is among others or, ore, ocf3, among others re is H, RF, RG, among others and M is 1, 2 or 3 n is 0, 1, 2, 3 or 4 and P is 0, 1, 2 or 3.Preferred compounds are: N - (2 - dimethylamino ethyl) - 4 - [4 - ((1R, 2R) - 1 - - - - ilamino metansulfonilamino indan 2 - trifluoromethyl - pyrimidin-2-yl) - 5 - 2 - 3 - methoxy - ilamino] benzamide, 4 - (4 - [(1R, 2R (metansulfonil) - 1 - methyl - 2 - amino) - indan ilamino] - 5 - trifluoromethyl - pyrimidine - 2 - 3 - methoxy - ilamino} - N - (1 - methyl - 4 - piperidin yl) - Ben Zamida, 2-fluoro-4 - (4 - (1R,Metansulfonil 2R) - 1 - methyl - 2 - indan) - amino] - 5 - (trifluoromethyl ilamino pyrimidine ilamino} - 2 - 5 - methoxy - N - (1 - methyl - 4 - piperidin yl) - benzamide, among others. It also relates to a Pharmaceutical composition. These compounds are inhibitors of the Enzyme ptk2 and are useful in the treatment of diseases related to excessive or abnormal Cell ProliferationREFERIDA A UN DERIVADO DE 2,4-DIAMINOPIRIMIDINA DE FORMULA (1), DONDE A ES ARILO C6-C15 O HETEROARILO DE 5 A 12 MIEMBROS B ES ARILO C6-C10 O HETEROARILO DE 5 A 10 MIEMBROS R1, R2, R4 Y Rx SON H, Ra, Rb, ENTRE OTROS R3 ES NRcRc, N(ORc)Rc, N[C(O)Rc]2, ENTRE OTROS R5 ES HALOGENO, CN, CO2, ORc, ENTRE OTROS Ra ES ALQUILO C1-C6, CICLOALQUILO C3-C10, ARILO C6-C10, ENTRE OTROS Rb ES =O, ORc, OCF3, ENTRE OTROS Rc ES H, Rd, Re, ENTRE OTROS Rd ES O, ORe, OCF3, ENTRE OTROS Re ES H, Rf, Rg, ENTRE OTROS m ES 1, 2 O 3 n ES 0, 1, 2, 3 O 4 p ES 0, 1, 2 O 3. SON COMPUESTOS PREFERIDOS: N-(2-DIMETILAMINO-ETIL)-4-[4-((1R,2R)-1-METANSULFONILAMINO-IND
