GUY FRANCIS DE ROSE,PATRICK F. M. MEEUS,NATHAN ANTHONY LOGAN CHUBB,TOM L. MTIER
申请号：
ARP140101988
公开号：
AR096346A1
申请日:
2014.05.19
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Also, a method of treatment of an animal with a parasitic infestation by Administering the composition of Action prolonged animal that needs.Claim 1: a long-acting composition, characterized in that it comprises: a) a Spiro - azetidin - isoxazolina selected of the formula (1) or (2) in which r u00b9 u1d43, r u00b9 u1d47 and r u00b9 u1d9c are each independently Hydrogen, Chlorine, Bromine, Fluorine or trifluoromethyl, and R u00b2 is Ethyl Propyl, Isopropyl, Isobutyl, ciclopropilo, - C (OH) (ch u2083 u2082, ch u2082 ciclopropilo) - - - - - ch u2082sch u2083 ch u2082oh ch u2082cf u2083,,,- ch u2082s ch u2083 - ch u2082s (OR), (OR) u2082ch u2083, ch u2082scf u2083 - 2.2 - 1.1 dioxidotietano difluorociclopropilo, -, and - ch u2082 - 1H pyrazole, and stereoisomers of them； (b) a Glycolic ether； c) at least one Food acceptable Solvent； d) optionally, at least one precipitation inhibitor option； and (e) Finally, at least one Antioxidant.Claim 2: the composition of claim 1, wherein the Spiro - azetidine is a compound of formula (1), and in which r u00b9 u1d43, r u00b9 u1d47 and r u00b9 u00b9 u1d9c are each independently Hydrogen, Fluorine or chlorine, and R u00b2 is ch u2082s u2082ch u2083 - (OR), and stereoisomers thereof.Claim 5: a topical Composition of long-acting, characterized in that it comprises: (a) to (S) - 1 - (5 - (5 - (3,5 - Dichloro - 4-fluorophenyl) - 5 - (trifluoromethyl) - 4.5 - dihidroisoxazol - 3 - yl) - 3h azetidin - 3.1 - spiro [isobenzofuran] - 1 - il) - 2 - (metiisuifonii) ethanone； (b) monobutil u00e9ter dietilenglic u00f3lico or Mon Oetil u00e9ter dietilenglic u00f3lico； c) at least one Food acceptable Solvent； d) optionally,At least one precipitation inhibitor； and e) optionally, at least one Antioxidant.Claim 6: Composition of Claim 5, wherein the Solvent is selected from dimetilisosorbida, caprylic / capric triglyceride, oleic acid, Isopropyl Myristate, eucalyptol, benzyl alcohol, Benzyl benzoate, ethanol, Propylene Glycol Caprylate, Iaurato p
