The invention relates to fatty acid stimulation of rectal mucosa initiatingthe process of defecation, acting as a laxative.Furthermore, the invention relates to the usage of free fatty acids, fattyacid mixtures and fatty acid extracts from marinelipids in pharmaceutical formulations such as suppositories, ointments,tablets and gelatin capsules for treatment and prevention ofmultiple disorders like constipation, hemorrhoids, bacterial infections (e.g.helicobacter pylori), viral infections (e.g. herpes simplexvirus infections) and inflammations, as well as against fissura ani andpruritus ani.