Karolina A. Hosiawa;John McWhirter;Robert Babb;Sean Stevens;David R. Buckler;Samuel Davis;Andrew J. Murphy;Lynn MacDonald
发明人:
Robert Babb,John McWhirter,Lynn MacDonald,Sean Stevens,Samuel Davis,David R. Buckler,Karolina A. Hosiawa,Andrew J. Murphy
申请号：
US13412936
公开号：
US20120192300A1
申请日:
2012.03.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline. Methods for making light chain variable regions in mice, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, are provided.
