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PREPARATIONS OF TAXANES FOR INTRAVENOUS ADMINISTRATION AND THE PREPARATION METHOD THEREOF
专利权人:
发明人:
Jianming Chen,Baoan Gao,Jing Sun,Yue Zhang,Xiaoli Zheng,Ying Li,Dan Guo,Yang Zhang,Zhongbin Wu,Qiuxia Yang,Wei Liu,Peng Gu
申请号:
US15274452
公开号:
US20170007570A1
申请日:
2016.09.23
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The invention relates to a preparation of taxanes for intravenous administration consisting of a drug solution and an emulsion. The drug solution consists of paclitaxel or docetaxel, a pH regulator and an organic solvent for injection. The emulsion includes a fat emulsion and is composed of oil for injection, an emulsifier, an antioxidant, an isotonic regulator, a stabilizer, a pH regulator and water for injection. When used, the drug solution at the clinical dosage can be added and evenly mixed in the emulsion to perform intravenous drip directly or the drug solution at the clinical dosage can also be firstly added into the emulsion with no less than 5 times volume of the drug solution and then a predetermined amount of normal saline or glucose solution for injection is added to perform intravenous drip. The preparation of the present invention does not contain solubilizer.
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