SHIN, Young Kee,신영기,KIM, Young Deug,김영덕,JUNG, Hun Soon,정헌순,KIM, Deuk Ae,김득애,HA, Tae Kyung,하태경
申请号：
KRKR2016/004867
公开号：
WO2016/182311A1
申请日:
2016.05.10
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
The present invention relates to a composition for cancer cell sensitization containing as an active ingredient a substance inhibiting the expression of an oncogene of a HPV virus, and more specifically, to a composition for radiosensitization which is used for the treatment of cancer induced by HPV infection and contains as an active ingredient oligonucleotide having any one nucleic acid sequence selected from the group consisting of sequence numbers 1 to 10. The oligonucleotide of the present invention inhibits the expressions of E6 and E7 which are HPV virus oncoproteins, thereby inhibiting the proliferation of tumor cells, and enhances the sensitivity of tumor cells to radiation, thereby exhibiting an excellent effect as a sensitizer that can maximize the cell death effect.La présente invention concerne une composition permettant la sensibilisation de cellules cancéreuses, contenant en tant que principe actif une substance inhibant lexpression doncogènes de papillomavirus (HPV), et plus spécifiquement, une composition pour la radiosensibilisation utilisée lors du traitement de cancers induits par une infection à HPV et contenant en tant que principe actif un oligonucléotide possédant une quelconque séquence dacide nucléique sélectionnée au sein du groupe constitué par les séquences numérotées de 1 à 10. Loligonucléotide de la présente invention inhibe lexpression de E6 et E7, lesquels sont des oncoprotéines des virus HPV, inhibant ainsi la prolifération des cellules tumorales, et augmente la sensibilité des cellules tumorales à lirradiation, présentant de ce fait un excellent effet en tant que sensibilisateur pouvant maximiser leffet de mort cellulaire.본 발명은 HPV 바이러스의 발암 유전자 발현 저해물질을 유효성분으로 포함 하는 암세포 감작용 조성물에 관한 것으로, 보다 상세하게는 서열번호 1 내지 10으 로 이루어진 군에서 선택되는 어느 하나의 핵산 서열을 갖는 올리고뉴클레오티드를 유효성분으로 포함하며, HPV 감염에 의해 유발된 암 치료에 이용되는 방사선 감작 용 조성물에 관한 것이다. 본 발명의 올리고뉴클레오티드는 HPV 바이러스의 발암성 단백질인 E6 및 E7 의 발현을 저해하여 종양세포의 증식을 억제하며, 방사선에 대한 종양세포의 민감 도를 증진시켜 세포사멸 효과를 극대화할 수 있는 감작제로서
