#$%^&*AU2017204449A120170720.pdf#####Il: grs Interwovn NRPortbl DCC GRS 14989015_l.docx-27 06/2017 Method of providing monoclonal auto-antibodies with desired specificity Abstract Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.
