Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A
发明人:
Jones, Philip,Ontoria Ontoria, Jesus Maria
申请号：
AU2010299664
公开号：
AU2010299664A1
申请日:
2010.09.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smo antagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
