Nathanael S. Gray,Sara Jean Buhrlage,Steven P. Treon,Hwan Geun Choi,Yuan Xiong,Guang Yang
申请号：
US16672198
公开号：
US20200165267A1
申请日:
2019.11.01
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure provides thiazolyl-containing compounds of Formula (I), (II), or (III). The compounds described herein may be able to inhibit protein kinases (e.g. Src family kinases (e.g. hemopoietic cell kinase (HCK)), Bruton's tyrosine kinase (BTK)) and may be useful in treating and/or preventing proliferative diseases (e.g. myelodysplasia, leukemia, lymphoma, (e.g. Waldenström's macroglobulinemia)) and in inducing apoptosis in a cell (e.g. malignant blood cell). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.
