The Industry & Academic Cooperation in Chungnam National University (IAC)
发明人:
Yeon Soo Kim,Moonkyung Kang,Min Jeong Baek
申请号：
US15365117
公开号：
US10039841B2
申请日:
2016.11.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a replication retrovirus vector system comprising thymidine kinase (HSV-TK) gene and cytosine deaminase (CD) gene which make gene transfer to cancer cell tissue for the efficient treatment of cancer. Particularly, the HSV-TK/CD combined self-replicating retrovirus vector system of the present invention characteristically contains both HSV-TK and CD genes； has no worries about losing a therapeutic gene because recombination does not occur in this system during virus infection； and has an excellent stability, and also is able to induce cancer cell death by using the prodrug GCV or 5-FC and can apply a therapeutic gene or a prodrug thereof selectively to such cancer that shows resistance against cancer treatment using either TK or CD, so that this system of the invention can be advantageously used as a pharmaceutical composition for the treatment of cancer.
