Hook, David,Riss, Bernhard,Kaufmann, Daniel,Napp, Matthias,Bappert, Erhard,Polleux, Philippe,Medlock, Jonathan,Zanotti-Gerosa, Antonio
申请号：
AU2012202949
公开号：
AU2012202949A1
申请日:
2012.05.18
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012202949A120120607.pdf#####C:\NRPonhlDCC\KXGWU1J65441 DOC-IM/20 12 ABSTRACT The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a y-amino-6-biphenyl-a-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester. R2 -N R3 R13 R1 (1) I1
