PROBLEM TO BE SOLVED: To provide a hair growth promoter, a hair regrowth promoter, or a remedy for alopecia by determining an endogenous factor inhibiting hair growth and performing screening for a substance inhibiting the activity or expression of the endogenous factor.SOLUTION: It is found that FGF18 inhibits hair growth, and a method for performing screening for an FGF18 activity inhibitor or an FGF18 gene expression inhibitor to use the inhibitor as a candidate for a hair growth promoter, a hair regrowth promoter, and a remedy for alopecia is provided. Further, a hair growth promoter, a hair regrowth promoter, or a remedy for alopecia containing an FGF18 activity inhibitor and/or an FGF18 expression inhibitor such as a partial peptide of FGF18 or a hot water extract of Momordica charantia as an active ingredient is also provided.COPYRIGHT: (C)2014,JPO&INPIT【課題】毛髪成長を阻害する内在性因子を決定し、当該内在性因子の活性もしくは発現を阻害する物質をスクリーニングして、毛髪成長促進剤、発毛促進剤又は脱毛症治療剤を提供すること。【解決手段】FGF18が毛髪成長を阻害することが見出され、FGF18活性阻害物質又はFGF18遺伝子発現阻害物質をスクリーニングして、毛髪成長促進剤、発毛促進剤及び脱毛症治療剤の候補とする方法が開示される。また、FGF18の部分ペプチド、ゴーヤー熱水抽出物などのFGF18活性阻害物質及び/又は発現抑制物質を有効成分として含有する毛髪成長促進剤、発毛促進剤又は脱毛症治療剤が開示される。【選択図】図2