BEIGHT, Douglas W.,COATES, David A.,JOSEPH, Sajan,MCMILLEN, William T.,PARTHASARATHY, Saravanan,PEI, Huaxing,SAWYER, Jason Scott,WOLFANGEL, Craig D.,ZHAO, Gaiying
申请号：
PH12017500635
公开号：
PH12017500635B1
申请日:
2017.04.06
申请国别(地区):
PH
年份:
2017
代理人:
摘要：
The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (TGFáR1), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, preferably colon cancer, melanoma, hepatocellular carcinoma, renal cancer, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung cancer, and gastric cancer, and/or fibrosis, preferably liver fibrosis and chronic kidney disease.
