您的位置: 首页 > 农业专利 > 详情页

COMPOUNDS FOR TARGETING DRUG DELIVERY AND ENHANCING SIRNA ACTIVITY
专利权人:
发明人:
NIITSU YOSHIRO,PAYNE JOSEPH E,HOU ZHENG,GAUDETTE JOHN A,SRIDHAR C NAGARAJAN,KNOPOV VICTOR,WITTE RICHARD P,AHMADIAN MOHAMMAD,PERELMAN LOREN A,TANAKA YASUNOBU,AKOPIAN VIOLETTA,KARMALI PRIYA
申请号:
IN10164/CHENP/2013
公开号:
IN2013CN10164A
申请日:
2013.12.20
申请国别(地区):
IN
年份:
2014
代理人:
摘要:
Here described are compounds of formula I: wherein Rand R is independently selected from a group consisting of C to C alkyl C to C alkenyl and oleyl group; wherein R and R are independently selected from a group consisting of C to C alkyl and C to C alkanol; wherein X is selected from a group consisting of CH S and O or absent; wherein Y is selected from (CH)n S(CH) O(CH) thiophene SO(CH) and ester wherein n = 1 4; wherein a = 1 4; wherein b=l 4; wherein c=l 4; and wherein Z is a counterion; and compounds consisting of the structure (targeting molecule) linker (targeting molecule) wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0 1 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG like molecule as well as compositions and pharmaceutical formulations including one or both of these compounds which are useful for the delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充