method for increasing intracellular copper level in an ischemic tissue, method for specifically delivering copper to cells of an ischemic tissue, method for inducing at least two tissue repair events in an ischemic tissue, method for inducing stem cell migration for an ischemic tissue, method for promoting copper-dependent hif-1 transcriptional activities in an ischemic tissue, pharmaceutical composition, use of a composition, composition and kit
These are repair and regeneration methods of ischemic tissue by promoting tissue redistribution and reuse of copper by administering a composition comprising a copper chelating tetramine such as trientine. methods and compositions for increasing intracellular copper level and / or inducing repair of an ischemic tissue in an individual. Increased copper level in an ischemic tissue may promote copper-dependent hif-1 transcriptional activities and tissue repair.trata-se de métodos de reparo e regeneração de tecido isquêmico através da promoção da redistribuição de tecido e reuso de cobre administrando-se uma composição que compreende uma tetramina quelante de cobre, tal como trientina. métodos e composições para aumentar o nível de cobre intracelular e/ou induzir reparo de um tecido isquêmico em um indivíduo. o nível de cobre aumentado em um tecido isquêmico pode promover atividades transcricionais de hif-1 dependentes de cobre e reparo de tecido.
