USE OF I) A POLYGLYCOL AND II) AN ACTIVE DRUG SUBSTANCE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION FOR I) MITIGATING THE RISK OF ALCOHOL INDUCED DOSE DUMPING AND/OR II) REDUCING THE RISK OF DRUG ABUSE
DOWNIE, KEN,PEDERSEN, ANDERS VAGNO,HAAHR, ANNE-METTE,HEMMINGSEN, PERNILLE HOYRUP,BAR-SHALOM, DANIEL
申请号：
NZ57756008
公开号：
NZ577560A
申请日:
2008.01.16
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is the use of i) one or more polyglycols selected from polyethylene glycols and/or polyethylene oxides and ii) one or more drug substances for the preparation of a pharmaceutical composition that is without ethanol induced dose dumping and wherein the drug substance is released by erosion of a matrix composition comprising said one or more polyethylene glycols and/or polyethylene oxides and said one or more drug substances, and wherein said matrix composition is partly coated with a polymer that is substantially insoluble, non-erodable and non-permeable to water leaving non-coated areas of the matrix exposed for release of the drug substance, wherein said polymer is selected from the group consisting of: ethylcellulose, cellulose acetate, cellulose propionate, cellulose nitrate, methylcellulose, carboxymethylcellulose and salts thereof, cellulose acetate phthalate, microcrystalline cellulose, ethylhydroxyethylcellulose, ethylmethylcellulose, hydroxyethylcellulose, hydroxyethylmethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxymethylcellulose and hydroxymethylpropylcellulose, poly(methyl)acrylates, polyamide, polyethylene, polyethylene terephthalate, polypropylenem polyurethane, polyvinyl acetate, polyvinyl chloride, silicone rubber, latex, polyhydroxybutyrate, polyhydroxyvalerate, teflon, polylactic acid or polyglycolic acid and copolymers thereof, the copolymers selected from the group consisting of ethylene vinyl acetate (EVA), styrene-butadienestyrene (SBS) and styrene-isoprene-styrene (SIS),copolymers of polylactic acid and polyglycolic acid and the co-polymer of methacrylategalactomannan.
