The present invention provides an indirect method and accompanying apparatus for supplying a high concentration of medicaments, particularly antibiotics, to the nasal sinuses by first loading the medicament into the cerebrospinal venous system (CVCS) via a Valsalva manuever. Because the CVCS is a valveless, three-dimensional closed system, traditional physiological dogma such as veins always draining tissues does not always apply. Instead, because in its closed-system blood can flow in any direction, the blood of the CVCS and any medicaments that it contains will be drawn to any portion of it where there is increased outflow, such as the copious venous-derived sinus fluid drainage present during nasal allergy or nasal infection. Thus, the very nasal congestion that impedes the effectiveness of direct medicament application, such as seen with nasal inhalers or systemic antibiotics, aids in applying the medicament indirectly to the nasal sinuses via the CVCS. Additionally, the present method has the benefit of delivering medicaments that, unlike present treatment regimens, are not limited solely to those medicaments that can be successfully absorbed from the G.I. tract. This means that, in the case of antibiotics, the bacteria infecting this portion of the CVCS will not be as resistant to treatment if they have not had prior exposure to this new line of antibiotics. Finally, if the infection extends to the eardrums, making the Valsalva maneuver painful, or if the patient is simply unusually sensitive, then earplugs to reduce the stress on the eardrums may be worn while the patient performs the Valsalva maneuver.본 발명은 약물을 발살바법을 통하여 뇌척수 정맥계(CVCS)에 먼저 적하하는 것에 의해 고농도의 약물, 특히 항생물질을 부비강에 공급하기 위한 간접 방법 및 수반되는 장치를 제공한다. 상기 CVCS는 판막이 없고, 3차원의 밀폐 계이기 때문에, 정맥은 언제나 배출 조직이라는 것과 같은 전통적인 생리학적 도그마가 언제나 적용되는 것은 아니다. 대신, 밀폐된 계 내에서 혈액이 어떤 방향으로도 흐를 수 있기 때문에, CVCS의 혈액 및 혈액이 함유하는 약물은 뇌척추 정맥계의 어느 부분으로도 갈 수 있고, 그곳에서 코 알레르기 또는 코 감염 동안 존재하는 다량의 정맥유도된 부비강 유체 배출과 같은 유출 증가가 존재한다. 따라서, 코 흡입기 또는 전신
