SYSTEM AND METHODS FOR DERIVING GENE SIGNATURE BIOMARKERS OF RESPONSE TO PD-1 ANTAGONISTS

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专利权人:

Merck Sharp & Dohme Corp.

发明人:

AYERS, Mark, D.,LOBODA, Andrey,LUNCEFORD, Jared, K.,MCCLANAHAN, Terrill, K.,MURPHY, Erin, E.,NEBOZHYN, Michael

申请号：

EP15868101

公开号：

EP3230498A4

申请日:

2015.12.08

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

A gene expression platform, which is a combination of a set of genes that are correlated with response to a PD-1 antagonist in multiple tumor types and a normalization gene set, is disclosed. A method and system of using the gene expression platform to derive gene signature biomarkers of anti-tumor response to a PD-1 antagonist and to test patient samples for predictive gene signature biomarkers are also disclosed.

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