Jennifer Watkins,Michael March Schmidt,Monia Draghi,Amanda Frank Oliphant,Sara Marie Halmos,Thomas Joseph Schuetz,Jason Michael Lajoie,Allison Nelson
申请号：
US16583797
公开号：
US20200079867A1
申请日:
2019.09.26
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer or inflammatory conditions mediated by autoreactive B cells in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize at least one tumor antigen or B-lineage cell antigen and NKp30 and/or another activating NK receptor. In some aspects, multispecific antigen-binding constructs are provided that recognize at least two tumor antigens or two antigens expressed by B-lineage cells, NKp30, and another activating NK receptor. The multispecific antigen-binding constructs and methods disclosed herein can be used for the treatment of cancer, even a cancer characterized by a CD16 deficient microenvironment and/or characterized by target cells (e.g., cancer cells) having a low level of expression of the tumor antigen.
