Compositions for the treatment of pain and/or inflammation comprising at leastone peptide with the general formula(I) R1-AA-R2, its stereoisomers, mixtures thereof, and its cosmetically andpharmaceutically acceptable salts. Peptide withgeneral formula (I), its stereoisomers, mixtures thereof, and its cosmeticallyand pharmaceutically acceptable salts for the treatmentof pain and/or inflammation.