BRUNKOW, MARY E.,GALAS, DAVID J.,KOVACEVICH, BRIAN,MULLIGAN, JOHN T.,PAEPER, BRYAN W.,VAN NESS, JEFFREY,WINKLER, DAVID G.,BRUNKOW, Mary E.,GALAS, David J.,KOVACEVICH, Brian,MULLIGAN, John T.,PAEPER, Bryan W.,VAN NESS,
申请号：
YUP20050932
公开号：
RS52769B
申请日:
2004.06.15
申请国别(地区):
YU
年份:
2013
代理人:
摘要：
A novel class or family of TGF-beta binding proteins is disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules. In particular, compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fracturesAntitelo, ili njegov fragment koji se vezuje za antigen, koji se vezuje za SEQ ID NO: 46 sa afinitetom KD manjim ili jednakim 10-6 M, gde pomenuto antitelo ili njegov fragmet se vezuje za amino kiselinsku sekvencu u okviru 57-146 od SEQ ID NO: 46.Prijava sadrži još 38 patentnih zahteva.
