1,4,7,10 - tetoraazashikurododekan - N, N and the N, N - four acetic acids (DOTA) in order to introduce, being simple vis-a-vis chemical compound, such as peptide being efficient, it offers the manner whose cost efficiency is good. Being the manner which introduces DOTA into chemical compound, 1st step and the said mixed liquid which produce the mixed liquid of DOTA and the dimethyl sulfoxide which do not possess the protective group, it includes with the 2nd step which is made to contact with the chemical compound which supports on the solid phase substrate, manner.ペプチドなどの化合物に対して1,4,7,10-テトラアザシクロドデカン-N,N,N,N-四酢酸(DOTA)を導入するための、簡便で効率的でコスト効率の良い方法を提供する。DOTAを化合物に導入する方法であって、保護基を有さないDOTAとジメチルスルホキシドとの混合液を作製する第1のステップと、該混合液を、固相担体上に担持された化合物と接触させる第2のステップとを含む、方法。
