A handset for an electroporation device having an improved signal generator. The signal generator includes a primary winding and a plurality of secondary windings where the plurality of secondary windings are coupled together in a series configuration. A storage capacitor and the fly-back diode are coupled to each of the plurality of secondary windings. The signal generator includes a signal amplifier, and a power switch. The power switch is configured to supply a voltage from a power source across the primary winding.