This therapeutic agent for chronic obstructive pulmonary disease comprises, an active ingredient, at least one of a 7-aminoquinolinone derivative represented by the general formula (I):wherein R1 represents a hydrogen atom or an alkyl group R2 and R3 each represents a group selected from a hydrogen atom, an acyl group, an alkyl group and an alkenyl group and R4 and R5 each represents a group selected from a hydrogen atom, an acyl group, an alkyl group, an alkenyl group and an aralkyl group, and its physiologically acceptable salt.
