對轉運治療性分子穿過血腦屏障的增强

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专利权人:

BIOGEN MA INC.

发明人:

FARRINGTON, GRAHAM, K.,SISK, WILLIAM

申请号：

HK15104429.6

公开号：

HK1203977A

申请日:

2015.05.11

申请国别(地区):

HK

年份:

2015

代理人:

摘要：

The invention is based, at least in part, on the finding that a dimeric version of a BBB-transmigrating antibody (e.g., the TMEM30A (CDC-50A) binding antibody, FC5) was found to greatly enhance transport across the BBB as compared to monovalent FC5 VHH. The invention provides, inter alia, molecules that increase transport of pharmacologically active agents across the blood brain barrier, methods for increasing transport across the blood brain barrier, and methods of treatment of disorders or diseases having a neurological component.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/