An ophthalmic stimulator for constricting a pupil of an eye comprises an irradiation control system, to generate an irradiation control signal an irradiation source, coupled to the irradiation control system, to generate an irradiation and an irradiation delivery system, coupled to the irradiation control system, to receive the irradiation from the irradiation source, and to deliver a patterned irradiation to an iris of the eye wherein the irradiation control system controls at least one of the irradiation source and the irradiation delivery system with the irradiation control signal so that the patterned irradiation causes a long-term constriction of the pupil of the eye.