The subject matter of the invention is the use of a substituted or non- substituted hydroxyapatite particle as a carrier of bioactive molecules for the prevention and treatment of grapevine trunk disease, in particular esca disease of the vines. In a preferred embodiment the hydroxyapatite is substituted by at least one carbonate ion, corresponding to the formula: Ca(10)(P04)(6-y)(C03)y(OH)2 wherein y is a number comprised between 0.002 and 0.030, and having a crystallinity degree comprised between 25 and 59 %. The invention also covers aggregates of these particles and compositions including these particles or aggregates.La présente invention concerne une particule d'hydroxyapatite substituée comprenant un agent bioactif, des agrégats de ces particules et des compositions comprenant ces particules ou agrégats, ainsi que leur utilisation pour traiter des plantes à des fins phytosanitaires et/ou nutritionnelles.
