Benjamin Alexander MAYES,Adel M. MOUSSA,Alistair James STEWART
申请号：
US14242671
公开号：
US20140294769A1
申请日:
2014.04.01
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided herein are compounds, methods and pharmaceutical compositions for use in treatment of viral infections, including hepatitis C virus (HCV) infections, in hosts in need thereof. In certain embodiments, the compounds are 2′,4′-fluoro nucleosides according to Formula 1001:or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein Base, RA, and PD are as described herein. In certain embodiments, 2′,4′-fluoro nucleosides are provided which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human.
