Laurence A. ROTH,James Anthony STEFATER, III,Tomasz Pawel STRYJEWSKI,John Solomon GARNER
申请号：
US16245960
公开号：
US20190216982A1
申请日:
2019.01.11
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention provides methods and polymer-containing formulations for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (a) a nucleo-functional polymer is a biocompatible polyalkylene polymer substituted by (i) a plurality of —；OH groups, (ii) a plurality of thio-functional groups —；R1—；SH wherein R1 is an ester-containing linker, and (iii) optionally one or more —；OC(O)—；(C1-C6 alkyl) groups, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups. Formulations are provided containing a nucleo-functional polymer, a poly(ethylene glycol) polymer, and an aqueous pharmaceutically acceptable carrier, for use in the therapeutic methods.
