Fujian Institute Of Research On The Structure Of Matter; Chinese Academy Of Sciences
发明人:
申请号：
EP12872724.5
公开号：
EP2752413A1
申请日:
2012.03.26
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
This invention provides a class of quinazoline compounds, as represented by formula (I), and their pharmaceutically acceptable salts,wherein: each of R1 and R2 independently, is selected from H, C1-C6 alkoxy, halo-C1-C6 alkoxy, C1-C6-alkoxy-C1-C6 alkoxy, C3-C8 cycloalkoxy, C3-C8 heterocycloalkoxy containing at least one of heteroatoms selected from N, O, S； Z is -NR4-, C(R5)2, S or -O-, wherein R4 is H or C1-C3 alkyl, R5 is the same or different, selected from H or C1-C3 alkyl； R3 is selected from H, halogen, C1-C6 alkyl, C1-C6 alkoxy or halo-C1-C6 alkyl； n is an integer from 0 to 5. This invention also provides methods of preparation and medical uses of the compounds of formula (I) and their pharmaceutically acceptable salts. These compounds have the activity of inhibiting EGFR-TK, and can be used as drugs for the treatment of protein tyrosine kinase related diseases such as tumours, cancers, etc.
