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MÉTODO DE TRATAMENTO E PREVENÇÃO DO HIPERPARATIROIDISMO SECUNDÁRIO
专利权人:
OPKO RENAL, LLC;OPKO IP HOLDINGS II, INC.; LLC;OPKO RENAL
发明人:
ERIC J. MESSNER,CHRISTIAN F. HELVIG,CHARLES W. BISHOP,KEITH H. CRAWFORD,MARTIN P. PETKOVICH
申请号:
PT07840277
公开号:
PT2037936E
申请日:
2007.06.21
申请国别(地区):
PT
年份:
2014
代理人:
摘要:
A method of treating elevated blood levels of iPTH by increasing or maintaining blood concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in a patient by administering, as necessary, both Vitamin D repletion and Vitamin D hormone replacement therapies, is disclosed. The blood concentrations of 25-hydroxyvitamin D are increased to and maintained at or above 30 ng/mL, and blood concentrations of 1,25-dihydroxyvitamin D are increased to or maintained within a patient's normal historical physiological range for 1,25-dihydroxyvitamin D without causing substantially increased risk of hypercalcemia, hyperphosphatemia or over suppression of plasma iPTH in the patient. The blood levels of 25-hydroxyvitamin D are maintained at or above 30 ng/mL between doses of Vitamin D repletion therapies, and the blood levels of 1,25-dihydroxyvitamin D are maintained in the patient's normal historical physiological range between doses of Vitamin D hormone replacement therapies. In one aspect, the disclosure includes methods wherein the blood concentration of 25-hydroxyvitamin D during treatment comprises predominantly 25-hydroxyvitamin D 3 , and/or wherein the method includes administering predominantly or solely 25-hydroxyvitamin D 3 for 25-hydroxyvitamin D repletion and/or maintenance.
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中国工程科技知识中心
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