抗降血鈣素基因相關胜肽(ANTI-CGRP)組成物及其用途农业专利-农业学术服务平台

发明人:: KOVACEVICH, BRIAN ROBERT,柯法席维屈　布莱恩Ｒ,柯法席維屈　布萊恩Ｒ,OLSON, KATIE,欧尔生　凯提,歐爾生　凱提,DUTZAR, BENJAMIN H.,杜萨　班杰明Ｈ,杜薩　班傑明Ｈ,BILLGREN, JENS J.,比尔葛林　珍斯Ｊ,比爾葛林　珍斯Ｊ,LATHAM, JOHN A.,雷特汉　约翰Ａ,雷特漢　約翰Ａ,MITCHELL, DANIELLE M.,柯法席维屈布莱恩R,柯法席維屈布萊恩R,欧尔生凯提,歐爾生凱提,杜萨班杰明H,杜薩班傑明H,比尔葛林珍斯J,比爾葛林珍斯J,雷特汉约翰A,雷特漢約翰A

摘要：: The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.本發明係有關於具有CGRP結合特異性之抗體及其片段。本發明的另一實施例係有關於本文中所述之抗體及其結合片段，其包含本文中所述之VH、VL與CDR多肽之序列以及編碼其等的聚核苷酸。本發明亦設想抗CGRP抗體及其結合片段與一或多種功能性或可檢測性基團複合之複合物。本發明亦設想製造該抗CGRP抗體及其結合片段之方法。本發明的實施例亦有關抗CGRP抗體及其結合片段用於診斷、評估與治療與CGRP相關聯的疾病與功能失調之用途。