PURPOSE: A bone cement for having a sustained drug release behavior is provided to resolve a problem of a drug effect not lasting for a predetermined time by allowing a fast initial burst of 10 to 20% of the drug actually included (burst: a concentration of a drug at a localized region being reduced to a treating range or less in time). CONSTITUTION: A bone cement comprises a drug, a bone cement matrix, and an amphiphilic additive. The amphiphilic additive is at least one selected from the group consisting of polyethylene oxide-polypropylene oxide copolymers, polyethylene oxide-polylactic acid copolymer, polyethylene oxide-polylactic acid copolymers, poly (ethylene oxide)-poly lactic glycolic acid copolymers, polyethylene oxide-polycaprolactone copolymers, polyethylene oxides, polyvinyl alcohols, polyoxyethylene alkyl ethers, polyoxyethylene Kester oil derivative, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene stearates. 0.1 to 40 parts by weight of the amphiphilic additive is included with respect to 100 parts by weight of the bone cement matrix. The drug is at least one selected from antibiotics, anticancer drugs, antimicrobial agents, antiphlogistics, and analgesics. [Reference numerals] (AA) Mix； (BB) Silicone mold； (CC) Drug containing amphiphilic additives/bone cement본 발명은 약물을 포함하는 골 시멘트 매트릭스, 및 양친매성 첨가제(amphiphilic additive)를 포함하는 골 시멘트에 관한 것으로, 본 발명에 따른 양친매성 첨가제가 포함된 약물 함유 골 시멘트는 국소 환부에 적용 시, 골 시멘트에 유의한 물성변화를 야기하지 않을 정도의 양친매성 첨가제를 첨가하여도 골 시멘트 내에 포함된 약물을 국소 환부에 보다 장기적이며 효율적으로 전달할 수 있어 현재까지 임상에서 선택의 여지없이 사용하고 있는, 시술 초기에만 항균효과를 가지는, 기존 약물 포함 골 시멘트를 대체할 수 있는 효과를 가진다.
