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Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents
专利权人:
Ferrokin Biosciences Inc.
发明人:
Hanko Jason A.,Zhang Huamin,Andres Patricia,Rienhoff Hugh Y.,Tapper Amy E.,Parent Stephan D.
申请号:
NZ60545209
公开号:
NZ605452A
申请日:
2009.07.14
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
Disclosed herein is a solid composition of Formula I, wherein the substituents are as defined within the specification and X is a counter ion, preferably selected from calcium, magnesium, potassium, sodium, zinc, betaine, choline hydroxide, diethanolamine, diethylamine, ethanolamine, hydroxyethyl morpholine, hydroxyethyl pyrrolidine, imidazole, N-methyl-d-glucamine (NMG), N,N’-dibenzyl-ethylenediamine, N, N’-diethyl-ethanolamine, piperazine, triethanolamine, tromethamine, Ca(OH)2, L-Iysine, L-arginine, Mg(OH)2, magnesium acetate, KOH, NaOH, Zn(OH)2, zinc acetate, Zn(OH)2/Mg(OH)2, EDA, L-histidine, 4-(2-hydroxyethyl morpho line), 1-(2- hydroxyethyl pyrrolidine), 1-(2-hydroxyethyl)-piperidine, potassium 2- ethylhexanoate, NaOAc, sodium 2-ethylhexanoate, 1,2-EDSA, HCI, H2S04, MSA, and p-TSA monohydrate.
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