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Imidazole compound and liposome containing same
专利权人:
FUJIFILM Corporation
发明人:
Toyohisa Oya,Ayumi Ishiyama,Naoyuki Nishikawa
申请号:
US15406050
公开号:
US09795566B2
申请日:
2017.01.13
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Provided are a novel imidazole compound which has a high stability of the compound itself; and a novel imidazole compound which is useful as a membrane-constituting lipid of liposomes. Disclosed are a compound represented by the following General Formula (1), and a liposome containing the same compound.In the formula, Z is an imidazolyl group which may be substituted, L1 is an alkylene group having 1 to 4 carbon atoms which may be substituted, X is an oxygen atom or a nitrogen-containing substituent, n is an integer of 2 to 4, m is an integer of 1 to 20, L2 is a divalent linking group having 1 to 6 carbon atoms, Y is a nitrogen-containing group, R1 and R2 are a hydrogen group or an alkyl group having 1 to 6 carbon atoms, R3 is a hydrogen atom or a substituent, and R4 and R5 are an alkyl group having 1 to 40 carbon atoms.
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