A kind of humanized antibody and chimeric antibody for specifically binding people's sclerostin is provided, the antibody can treat people's bone metabolism related diseases such as osteoporosis etc. with what.提供了一種特異性結合人硬骨素的人源化抗體和嵌合抗體,所述抗體可用於治療人骨代謝相關疾病如骨質疏鬆症等。