CHUANG, LU TE,庄路德,莊路德,SHEN, FWU MING,沈福铭,沈福銘,HUANG, YU LUNG,黄于陇,黃于隴
申请号：
TW099116626
公开号：
TWI397522B
申请日:
2010.05.25
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
A kind of 7,11,14- eicosatrienoic acid of △ (△ 7,11,14-eicosatrienoic acid,Call △ 7-ETrA in the following text) method for making,Including following all steps: 1. from pine-seed oil saponification,Pine nut oleic acid (PNA) is concentrated in the form of free fatty acid with extraction for urea saturation； 2. free fatty acid is esterified； 3. aliphatic ester is refined； 4. by aliphatic ester bromination； 5. bromide is reacted with 2,4,4- trimethyl -2- oxazoline (2,4,4-trimethyl-2-oxazoline)； 6. dimethyloxazoline reactant to be transformed into the long-chain unsaturated fatty acid of 20 carbon； And 7. utilize liquid chromatography carry out △ 7-ETrA isolation and purification； A kind of composition,Including △ 7-ETrA and carrier； And a kind of anti-inflammatory application of △ 7-ETrA and the composition.一種△7,11,14-二十碳三烯酸(△7,11,14-eicosatrienoic acid，下稱△7-ETrA)之製成方法，包括下列諸步驟：1.從松子油皂化、尿素飽和與萃取將松子油酸(PNA)以游離脂肪酸的形式濃縮；2.將游離脂肪酸酯化；3.將脂肪酸酯醇化；4.將脂肪酸酯溴化；5.將溴化物與2,4,4-三甲基-2-唑啉(2,4,4-trimethyl-2-oxazoline)反應；6.將dimethyloxazoline反應物轉變成二十個碳的長鏈不飽和脂肪酸；及7.利用液相層析法進行△7-ETrA分離與純化；一種組合物，包括△7-ETrA和載劑；及一種△7-ETrA與該組合物之抗發炎應用。
