The present invention is concerned with indolin-2-one and 1,3-dihydro-pyrrolo[3,2-c]pyridin-2-one derivatives of general formula wherein Ar1, Ar2, R1, R2, R3, X and n are as defined herein, as well as with a pharmaceutically acceptable salts thereof, with a racemic mixture, or with its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof, for use in the treatment of certain central nervous system disorders which are positive (psychosis) and negative symptoms of schizophrenia, substance abuse, alcohol and drug addiction, obsessive-compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, major depression, treatment resistant depression, anxiety disorders, Alzheimer’s disease, autism, Parkinson’s disease, chronic pain, borderline personality disorder, sleep disturbances, chronic fatigue syndrome, stiffness, antiinflammatory effects in arthritis and balance problems.本發明係關於以下通式之吲吲哚啉-2-酮及1,3-二氫-吡咯并[3,2-c]吡啶-2-酮衍生物：其中Ar1、Ar2、R1、R2、R3、X及n如本文所定義。以及其醫藥上可接受之鹽、外消旋混合物或其相應鏡像異構物及/或光學異構物及/或立體異構物，其用於治療某些中樞神經系統病症，該等中樞神經系統病症為精神分裂症之正性(精神病)及負性症狀、藥物濫用、酒精及藥物成癮、強迫病症、認知損傷、雙極性病症、情緒病症、重度抑鬱症、難治性抑鬱症、焦慮症、阿茲海默氏病(Alzheimer’s disease)、自閉症、帕金森氏病(Parkinson’s disease)、慢性疼痛、邊緣性人格病症、睡覺障礙、慢性疲勞症候群、僵硬、於關節炎中之抗炎效應及平衡問題。
