Disclosed is a method of reducing the appearance of a fine line or wrinkle on skin. The method can include topically applying to the fine line or wrinkle a composition comprising an effective amount of 1,4-dioxacycloheptadecane-5,17-dione and methyl 3-oxo-2-pentylcyclopentanecarboxylate to reduce matrix metalloprotease (MMP)-9 activity in the skin, wherein topical application of the composition reduces MMP-9 activity in the skin and reduces the appearance of the fine line or wrinkle on the skin.
