Memorial Sloan-Kettering Cancer Center;Agenus Inc.;Ludwig Institute for Cancer Research Ltd.
发明人:
Ana M. GONZALEZ,Nicholas S. WILSON,Dennis J. UNDERWOOD,Volker SEIBERT,Olivier LÉGER,Marc VAN DIJK,Roberta ZAPPASODI,Taha MERGHOUB,Jedd David WOLCHOK,David SCHAER,Gerd RITTER,Takemasa TSUJI
申请号：
US15962752
公开号：
US20180355051A1
申请日:
2018.04.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
