This Hair bright nucleic acid molecules for being related to the anti-RANKL Kang Body Knitting Code The Kang Body of full source of people of bright with being related to the full source Ren Kang Body Ju Body this Hair of and the purposes being related in the Drug object of the Kang Body System Prepare diseases such as the broken Bad Huo Swollen Liu Gu Turn shifting of the thin Pine, Off Festival inflammation bone dissolution of what Fang Zhi With Gu Damage Shi Xiang Off Ji Bing Te Do Shi Gu Quality comprising the The Kang Body Group conjunction bright It of this Hair of object ,. The bright Kang Body Bao Chi With people RANKL Te Iso Knot of this Hair closes And and hinders its active Tong Time of Broken, reducing its potential inhibitive ability of immunity , Tong Time of Right Ren Body has better Steady qualitative, avoids the drawbacks of Pi Quality Liang Kam of inhomogeneity (Iso Quality) Give that IgG2 Kang Body is produced determines Tapes Come.本發明涉及全人源化抗體，具體地，本發明涉及全人源抗RANKL抗體，編碼該抗體的核酸分子以及包含該抗體的組合物，本發明還涉及所述抗體在製備用於防治與骨損失相關疾病特別是骨質疏鬆、關節炎骨溶解破壞或腫瘤骨轉移等疾病的藥物中的用途。本發明的抗體在保持與人RANKL特異結合，並阻斷其活性的同時，降低了其對人體潜在的免疫抑制性，同時具有更好的穩定性，避免了IgG2抗體生産的不均一性（異質性）給批次質量鑒定帶來的弊端。
