Photodynamic bone stabilization and drug delivery systems include an insertion catheter (101) having an inner void (110) for passing at least one light-sensitive liquid, and an inner lumen (120) an expandable portion (400) releasably engaging a distal end (114) of the insertion catheter (101), wherein the expandable portion (400) comprises an inner expandable portion (410) in communication with the inner lumen (110) of the insertion catheter (101) and sufficiently designed to maintain a light-sensitive liquid therein and an outer expandable portion (450), surrounding the inner expandable portion (410), sufficiently designed to house and release at least one additive from the outer expandable portion (450) in an outward direction from the inner expandable portion (410) and a light-conducting fiber sized to pass through the inner lumen (110) of the insertion catheter (101) and into the inner expandable portion (410) for delivering light energy to the light-sensitive liquid.