<;P>;PROBLEM TO BE SOLVED: To obtain a medicine and a food and beverage which have a promotion action on IL-10 production, are taken for a long period of time and have high safety. <;P>;SOLUTION: The IL-10 production promoter is obtained by combining a bacterium, yeast or a treated microorganism having no IL-12 production inducing ability with a bacterium having IL-12 production inducing ability. <;P>;COPYRIGHT: (C)2008,JPO&INPIT