DOTSON JENNAFER,HEFFRON TIMOTHY,KRINTEL SUSSIE LERCHE,NDUBAKU CHUDI,SALPHATI LAURENT,WEI BINQING,HEALD ROBERT ANDREW,JONES GRAHAM ELGIN,MCLEAN NEVILLE JAMES,OLIVERO ALAN G,WANG LAN
申请号：
ZA201304128
公开号：
ZA201304128B
申请日:
2013.06.05
申请国别(地区):
ZA
年份:
2014
代理人:
摘要：
Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, antiinflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro , in situ , and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions. Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.
